ILGA (Infertility-Linked Genotype Analysis) – Genetic Test for Infertility Diagnosis

RepromedaLab introduces the specialized genetic panel ILGA, designed for a comprehensive examination of genes associated with infertility in couples undergoing reproductive treatment. This innovative test provides key insights for diagnosis and infertility treatment optimization, assisting doctors in selecting the most appropriate treatment strategy.

Diagnostic Benefits of the Panel

Genetic testing identifies genetic variants linked to infertility in both women and men. The test results can have a significant impact on decisions regarding assisted reproduction. It focuses on genetic factors that may cause:

• Primary ovarian insufficiency, oocyte maturation disorders in women, or abnormal embryonic development.

• Severe sperm abnormalities in men, including:

  • Oligospermia (low sperm count),

  • Teratospermia (abnormal sperm morphology),

  • Azoospermia (absence of sperm in ejaculate).

• Genetic defects affecting the fertilization capability of oocytes in both sexes.

Genes and variants associated with an increased risk of pregnancy loss.

Genes Analyzed

The ILGA panel covers a wide range of genes associated with infertility. The current list of tested genes is subject to change over time.

Genes Tested in Women:

AMHR2, ANXA5, AR, BMP15, CAPN10, CDC20, CLPP, CYP11A1, CYP17A1, CYP19A1, EIF2B2, EIF2B4, EIF2B5, ESR1, FANCM, FGF17, FGF8, FGFR1, FIGLA, FMR1, FOXL2, FSHB, FSHR, GALT, GDF9, GNRH1, GNRHR, HARS2, HFM1, HS6ST1, HSD17B4, IRS1, KISS1, KISS1R, LARS2, LHB, LHCGR, LHX3, LHX4, MCM8, MCM9, NLRP5, NOBOX, NR5A1, NUP107, PADI6, PATL2, POF1B, PSMC3IP, REC114, SEMA3A, SOHLH1, STAG3, SYCE1, SYCP3, TAC3, TACR3, TAF4B, TLE6, TUBB8, WEE2, ZP1, ZP2, ZP3.

Note: For the FMR1 gene, the number of CGG trinucleotide repeats is analyzed.

Genes Tested in Men:

ACTL7A, ACTL9, ADGRG2, AMHR2, ANOS1, ANXA5, AR, AURKC, CATSPER1, CATSPER2, CFAP43, CFAP44, CFAP69, CFTR, CLPP, DNAH1, DPY19L2, FANCM, FGF17, FGF8, FGFR1, FSHB, FSHR, GNRH1, GNRHR, HFM1, HS6ST1, INSL3, IQCN, KISS1, KISS1R, KLHL10, M1AP, NANOS1, NR5A1, PLCZ1, PMFBP1, PROK2, PROKR2, REC114, SLC26A8, SOHLH1, SOX3, SPATA16, SRY, STAG3, SUN5, SYCE1, SYCP3, TACR3, TAF4B, TEX11, TEX14, TEX15, USP26, USP9Y, WDR11, ZMYND15.

Special Analysis: The panel also detects Y chromosome microdeletions (AZF a, b, c), which can affect sperm production.

Clinical Application for Partner Centers

The test provides valuable insights for personalized infertility treatment. Based on the results, treatment strategies can be adjusted to ensure that the most suitable assisted reproduction method is selected for each couple.

• In women with genetically determined ovarian insufficiency, IVF with donor eggs may be recommended.

• In men with azoospermia, the test can help identify candidates for TESE (testicular sperm extraction).

  
  

Would you like to learn more about the test? Contact us at repromedalab@repromeda.cz.