New GOH method helps improve embryo assessment in PGT-A
- Jun 11
- 1 min read
In our new paper in Reproductive BioMedicine Online, we introduce Gain of Heterozygosity analysis (GOH) — a simple algorithm that can identify meiotic trisomies during PGT-A using genetic data from the embryo only.
Why does this matter?
Not all trisomies have the same meaning for embryo development. Some arise during the formation of the egg or sperm and usually represent a serious chromosomal problem. Others occur later during embryo cell divisions and may be related to mosaicism, where the embryo can still continue developing.
How does the GOH method work?
GOH is based on a simple signal: an increase in heterozygosity in the embryo’s genetic data. This means that no maternal or paternal DNA sample is needed, and no additional haplotyping is required.
Validation results
In our validation, GOH correctly identified 200 out of 205 evaluable meiotic trisomies, reaching 97.6% sensitivity.
Contribution to more precise embryo assessment
GOH therefore adds another useful layer to standard PGT-A interpretation. It may help distinguish serious chromosomal errors from mosaic findings and support more precise embryo assessment in clinical practice.
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